Zhang,Zhihong

Brief Bio

Dr. Zhang received her M.S. degree in Molecular Immunology from Tongji Medical University in 1999 and M.D.&Ph.D. degree in Biomedical engineering from HUST in 2003. Her M.D.&Ph.D. thesis "Tumors Metabolic Imaging Using the Intrinsic and Extrinsic Fluorescent Molecular Beacon" was awarded as Outstanding Doctorate Dissertation Award of Hubei Province (8^th). In July 1999, she joined Britton Chance Center for Biomedical Photonics in Huazhong University of Science and Technology, and later was promoted to Associate Professor (2004) and Full Professor (2008). Meanwhile, she worked with Dr. Britton Chance and Dr. Gang Zheng in the field of tumor metabolic imaging at University of Pennsylvania as visiting scholar from April 2002 to May 2003. She visited Dr. Gang Zheng’s lab at Ontario Cancer Institute / university of Toronto several times as postdocotoral fellow and cooperator during April 2007 to September 2011. 

Research Areas

Intravital optical molecular imaging for tumor immune;

Multi-functional nanocarriers for tumor imaging and therapeutics. 

Publications

1. Liang Wang, Min Chen, Jie Yang, Zhihong Zhang*. LC3 fluorescent puncta in autophagosomes or in protein aggregates can be distinguished by FRAP analysis in living cells. Autophagy. Accepted, 2013. (IF=7.453)

2. Honglin Jin,Juan Chen, Jonathan F. Lovell, Zhihong Zhang*,and Gang Zheng*. Synthesis and Development of Lipoprotein-Based Nanocarriers for Light-Activated Theranostics. Isr. J. Chem. 2012, 52,715-727. (Cover paper)

3. Ting Su, Xiangyong Li, Nisha Liu, Shaotao Pan, Jinling Lu, Jie Yang, and Zhihong Zhang*. Real-time imaging elucidates the role ofH₂O₂ in regulating kinetics of EGF-induced and Src-mediated tyrosinephosphorylation signaling. Journal of Biomedical Optics. 17(7), 076015, 2012. (IF=3.157)

4. Haiming Luo, Jiyun Shi, Honglin Jin, Di Fan, Lisen Lu, Fan Wang*, and Zhihong Zhang*.An ¹²⁵I-labeled octavalent peptide fluorescent nanoprobe for tumor-homing imaging in vivo. Biomaterials.33 (19): 4843-4850, 2012 (IF=7.404)

5. Honglin Jin, Jonathan F Lovell, Juan Chen, Qiaoya Lin, Lili Ding, Ken Ng, Rajendra Pandey, Muthiah Manoharan,Zhihong Zhang*, and Gang Zheng*. Mechanistic insights into LDL nanoparticle-mediated siRNA delivery.Bioconjugate Chemistry. 23 (1): 33–41, 2012. (IF=4.93)

6. Ting Su, Zhihong Zhang*, Qingming, Luo. Ratiometric fluorescence imagingof dual bio-molecular events in single living cells using a new FRET pair mVenus/mKOκ-based biosensor and a single fluorescent protein biosensor. Biosensors and Bioelectronics.31 (1): 292-298, 2012.(IF=5.602)

7. Haiming Luo, Jie Yang, Honglin Jin, Chuan Huang, Jianwei Fu, Fei Yang, Hui Gong, Shaoqun Zeng, Qingming Luo, andZhihong Zhang*. Tetrameric Far-Red Fluorescent Protein as a Scaffold to Assemble an Octavalent Peptide Nanoprobe for Enhanced Tumor Targeting and Intracellular Uptake In Vivo. FASEB J. 25(6):1865-1873, 2011. (IF=5.712)

8. Jie Yang, Zhihong Zhang*, Xin A. Zhang and Qingming Luo. A ligation-independent cloning method using nicking DNA endonuclease. BioTechniques. 49(5): 817-821, 2010. (IF=2.669)

9. Zhihong Zhang, Juan Chen, Lili Ding, Honglin Jin, Jonathan F. Lovell, Ian Corbin, Weiguo Cao, Pui-Chi Lo, Mi Yang, Ming-Sound Tsao, Qingming Luo, Gang Zheng, HDL-mimicking peptide-lipid nanoparticles with improved tumor targeting. Small. 6(3):430-437, 2010.( IF=8.349)

10. Zhihong Zhang, Weiguo Cao, Honglin Jin, Jonathan F. Lovell, Mi Yang, Lili Ding, Juan Chen, Ian Corbin, Qingming Luo, Gang Zheng. Biomimetic Nanocarrier for Direct Cytosolic Drug Delivery. Angewandte Chemie International Edition. 48(48), 9171-9175, 2009.(IF=13.455)

11. Jun Chu, Zhihong Zhang, Ying Zheng, Jie Yang, Linsong Qin, Jinling Lu, Zhenli Huang, Shaoqun Zeng, Qingming Luo. A novel far-red bimolecular fluorescence complementation system that allows for efficient visualization of protein interactions under physiological conditions. Biosensors and Bioelectronics 25(1): 234-239, 2009.(IF=5.602)

12. Zhihong Zhang, Juqiang Lin, Yan Ma, Shaoqun Zeng, Qingming Luo. Activation of Caspases-3 noninvolved in the bystander effect of HSV-tk/GCV system.Journal of Biomedical Optics.13(3), 031209, 2008.( IF=3.157)

13. Zhihong Zhang, Jie Yang, Jinling Lu, Juqiang Lin, Shaoqun Zeng, Qingming Luo. Fluorescence imaging to assess the matrix metalloproteinase (MMP) activity and its inhibitor in vivo.Journal of Biomedical Optics. 13(1), 011006, 2008. (IF=3.157, Cover paper)

14. Jinling Lu, Jun Chu, Jie Yang, Shaoqun Zheng, Qingming Luo, Zhihong Zhang*. Detection of β–Secretase Dimerization in Living Cells Using Acceptor Photobleaching FRET. Progress in Biochemistry and Biophysics, 35(3), 268-273, 2008.(Cover paper)　

15. Jie Yang, Zhihong Zhang, Juqiang Lin, Jinling Lu, Bi-feng Liu, Shaoqun Zeng, Qingming Luo. Detection of MMP activity in living cells by a genetically encoded surface-displayed FRET sensor. BBA-Molecular cell research, 1773(3): 400-407, 2007(Co-first author, IF=5.538)

16. Jinling Lu, Zhihong Zhang, Jie Yang, Jun Chu, Pengcheng Li, Shaoqun Zeng, Qingming Luo. Visualization of β-Secretase Cleavage in Living Cells Using a Genetically Encoded Surface-displayed FRET Biosensor. Biochemical and Biophysical Research Communications,362(1): 25-30, 2007   (Co-first author,IF=2.484)

17. Juqiang Lin,Zhihong Zhang, Shaoqun Zeng, Shixia Zhou, Bi-Feng Liu, Qian Liu, Jie Yang, Qingming Luo. TRAIL-induced apoptosis proceeding from caspase-3-dependent and -independent pathways in distinct HeLa cells. Biochemical and Biophysical Research Communications, 346, 1136–1141, 2006(Co-first author, IF=2.484)

18. Juqiang Lin,Zhihong Zhang, Jie Yang, Shaoqun Zeng,Bi-Feng Liu,Qingming Luo. Real-time detection of caspase-2 activation in a single living HeLa cell during cisplatin-induced apoptosis, Journal of Biomedical Optics, 11(2), 024011��strong>2006 (Co-first author, IF=3.157)

19. Zhihong Zhang, Hui Li, Qian Liu, Lanlan Zhou, Ming Zhang, Qingming Luo, Jerry Glickson, Britton Chance, and Gang Zheng.Metabolic Imaging of Tumors Using Intrinsic and Extrinsic Fluorescent Markers.Biosensors & Bioelectronics.20(3): 643-650, 2004. (IF=5.602)

20. Zhihong Zhang,Dana Blessington, Theresa M. Busch, Jerry Glickson, Qingming Luo, Britton Chance and Gang Zheng. Redox ratio of mitochondria as an indicator for the response of Photodynamic Therapy. Journal of Biomedical Optics. 2004, 9(4): 772-778.  (IF=3.157)

21. Min Zhang, Zhihong Zhang, Dana Blessington, Hui Li, Theresa M. Busch, Vanessa Madrak, Jeremy Miles, Britton Chance, Jerry D. Glickson, and Gang Zheng. Pyropheophorbide 2-Deoxyglucosamide: A New Photosensitizer Targeting Glucose transporters. Bioconjugate Chemistry. 14(4): 709-714, 2003. (Co-first author,IF=4.93)

22. Zhang, ZH; Zeng, SQ; Luo, QM, et al. Multi-photon excitation imaging of 5-HT visible fluorescence in live cells. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 29(2): 288-292, 2002

Awards and Honors

2006    Outstanding Doctorate Dissertation Award of Hubei Province

              Title: Tumors Metabolic Imaging Using the Intrinsic and Extrinsic Fluorescent Molecular Beacon 

2008    New Century Excellent Talent project of the Ministry of Education of China

2008    Outstanding Nanomedicine Research, third place in the poster competition in Sixth International nanomedicine and drug delivery symposium (NanoDDS’08)

2008    The first class prize for Natural Science Award of Hubei Province (2^nd person who complete the project)

              Title: Dynamic Monitoring Theory and Method of Optical Molecular Imaging for Drug Screening and Evaluation   

2010    The second class prize for National Natural Science Award of China (5^th person who complete the project)

             Title: On the mechanisms of optical imaging with femtosecond laser for biological function